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CD25 deficiency or interleukin 2 receptor alpha deficiency is an immunodeficiency disorder associated with mutations in the interleukin 2 receptor alpha (CD25) (IL2RA) gene. The mutations cause expression of a defective α chain or complete absence thereof, an essential part of high-affinity interleukin-2 (IL-2) receptors.
Homodimeric alpha chains (IL2RA) result in low-affinity receptor (Kd ~10−8M) with no signalling ability, while dimeric beta and gamma chains produce a medium-affinity receptor (Kd ~10−9M). Moreover, CD25 is an exclusive subunit that entirely binds IL-2, while CD132 binds the shared γc family cytokines (IL-4, IL-7, IL-9, IL-15 and IL-21 ...
IL-2 binds to the IL-2 receptor, which has three forms, generated by different combinations of three different proteins, often referred to as "chains": α (alpha) (also called IL-2Rα, CD25, or Tac antigen), β (beta) (also called IL-2Rβ, or CD122), and γ (gamma) (also called IL-2Rγ, γ c, common gamma chain, or CD132); these subunits are also parts of receptors for other cytokines.
The IL-15 receptor is composed of three subunits: IL-15R alpha, CD122, and CD132.Two of these subunits, CD122 and CD132, are shared with the receptor for IL-2, but IL-2 receptor has an additional subunit ().
16183 Ensembl ENSG00000109471 ENSMUSG00000027720 UniProt P60568 P04351 RefSeq (mRNA) NM_000586 NM_008366 RefSeq (protein) NP_000577 NP_032392 Location (UCSC) Chr 4: 122.45 – 122.46 Mb Chr 3: 37.17 – 37.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin-2 (IL-2) is an interleukin, which is a type of cytokine signaling molecule forming part of the immune system. It is a ...
237313 Ensembl ENSG00000016402 ENSMUSG00000020007 UniProt Q9UHF4 Q6PHB0 RefSeq (mRNA) NM_001278722 NM_001278723 NM_001278724 NM_014432 NM_172786 RefSeq (protein) NP_001265651 NP_001265652 NP_001265653 NP_055247 NP_766374 Location (UCSC) Chr 6: 137 – 137.05 Mb Chr 10: 19.59 – 19.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 20 receptor, alpha subunit, is a subunit ...
Interleukin-10 receptor (IL-10R) is a type II cytokine receptor. The receptor is tetrameric , composed of 2 α [ 1 ] and 2 β [ 2 ] subunits. The α subunit (encoded in the Il10ra gene) is expressed on haematopoietic cells (such as T, B, NK, mast, and dendritic cells ) whilst the β subunit (encoded in the Il10rb gene ) is expressed ubiquitously.
Interleukin 10 receptor, beta subunit is a subunit for the interleukin-10 receptor. IL10RB is its human gene. [5] IL10RB has also been designated CDw210b (cluster of differentiation w210b). The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex.