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Methotrexate was originally developed and continues to be used for chemotherapy, either alone or in combination with other agents.It is effective for the treatment of several cancers, including solid tumours of breast, head and neck, lung, bladder, as well as acute lymphocytic leukemias, non-Hodgkin's lymphoma, osteosarcoma, and choriocarcinoma and other trophoblastic neoplasms.
One solution is high-dosage methotrexate (IV HD-MTX), defined as ≥5 g/m2, administered by intravenous injection. [7] IV HD-MTX is delivered in addition to standard R-CHOP chemotherapy consisting of rituximab, a monoclonal antibody; cyclophosphamide, doxorubicin and vincristine, chemotherapy drugs; and prednisolone, a corticosteroid ...
Intrathecal administration is a route of administration for drugs via an injection into the spinal canal, or into the subarachnoid space so that it reaches the cerebrospinal fluid (CSF). It is useful in several applications, such as for spinal anesthesia, chemotherapy, or pain management. This route is also used to introduce drugs that fight ...
Administration of high doses of intravenous corticosteroids, such as methylprednisolone, is the routine therapy for acute relapses. This is administered over a period of three to five days, and has a well-established efficacy in promoting a faster recovery from disability after an attack.
Simple blood tests are also available for dose optimization of methotrexate, [32] 5-FU, paclitaxel, and docetaxel. [33] [34] The serum albumin level immediately prior to chemotherapy administration is an independent prognostic predictor of survival in various cancer types. [35]
Methotrexate is a folic acid analogue. It binds dihydrofolate reductase and prevents synthesis of tetrahydrofolate . It is used in the treatment of autoimmune diseases (for example rheumatoid arthritis or Behcet's Disease) and in transplantations.
President Donald Trump is meeting with Japanese Prime Minister Shigeru Ishiba in a high-stakes visit for a key ally that depends on the United States for security and trade. At the top of the ...
While route of administration is often used interchangeably with drug delivery, the two are separate concepts. Route of administration refers to the path a drug takes to enter the body, [ 10 ] whereas drug delivery also encompasses the engineering of delivery systems and can include different dosage forms and devices used to deliver a drug ...