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Fenfluramine was developed in the early 1960s and was first introduced for medical use as an appetite suppressant in France in 1963 followed by approval in the United States in 1973. [8] In the 1990s, fenfluramine came to be associated with cardiovascular toxicity, and because of this, was withdrawn from the United States market in 1997.
FDA approval as a treatment for malaria was swift. Most notably, phase III safety and tolerability trials were skipped. [5] The drug was first approved in Switzerland in 1984 by Hoffmann-LaRoche, [32] who brought it to market with the name Lariam. [33] However, mefloquine was not approved by the FDA for prophylactic use until 1989.
Tolrestat (AY-27773) is an aldose reductase inhibitor [1] which was approved for the control of certain diabetic complications. [2]While it was approved for marketed in several countries, it failed a Phase III trial in the U.S. due to toxicity and never received FDA approval.
Trifluoromethyl group covalently bonded to an R group. The trifluoromethyl group is a functional group that has the formula-CF 3. The naming of is group is derived from the methyl group (which has the formula -CH 3), by replacing each hydrogen atom by a fluorine atom. Some common examples are trifluoromethane H– CF 3, 1,1,1-trifluoroethane H ...
Triflupromazine (Vesprin) is an antipsychotic medication of the phenothiazine class. Among different effects of triflupromazine indication for use of this drug is severe emesis and severe hiccups . [ 1 ] [ 2 ] Due to its potential side effects (triflupromazine has higher risk for side effects than many other antipsychotics) it is not gold ...
Most FDA-approved prescription-only medications have a clearly understood mechanism of action for increasing blood flow to the privates. Currently, there are four FDA-approved prescription oral drugs.
5-Trifluoromethyl-2-aminoindane (TAI) is a drug of the 2-aminoindane group with putative entactogenic effects. It functions as a selective serotonin releasing agent (SSRA). TAI is the aminoindane analogue of norfenfluramine and is approximately 50% as neurotoxic in comparison.
Trifluoperazine, marketed under the brand name Stelazine among others, is a typical antipsychotic primarily used to treat schizophrenia. [3] It may also be used short term in those with generalized anxiety disorder but is less preferred to benzodiazepines. [3]
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