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  2. Drug discovery - Wikipedia

    en.wikipedia.org/wiki/Drug_discovery

    Another method for drug discovery is de novo drug design, in which a prediction is made of the sorts of chemicals that might (e.g.) fit into an active site of the target enzyme. For example, virtual screening and computer-aided drug design are often used to identify new chemical moieties that may interact with a target protein.

  3. Virtual screening - Wikipedia

    en.wikipedia.org/wiki/Virtual_screening

    Virtual screening has been defined as "automatically evaluating very large libraries of compounds" using computer programs. [4] As this definition suggests, VS has largely been a numbers game focusing on how the enormous chemical space of over 10 60 conceivable compounds [ 5 ] can be filtered to a manageable number that can be synthesized ...

  4. Peter Coveney - Wikipedia

    en.wikipedia.org/wiki/Peter_Coveney

    Peter V. Coveney is a British chemist who is Professor of Physical Chemistry, Honorary Professor of Computer Science, and the Director of the Centre for Computational Science (CCS) [2] and Associate Director of the Advanced Research Computing Centre at University College London (UCL).

  5. Free-energy perturbation - Wikipedia

    en.wikipedia.org/wiki/Free-energy_perturbation

    Other applications are the virtual screening of ligands in drug discovery, in silico mutagenesis studies [2] [3] and antibody affinity maturation. [4] For the study of reactions it is often necessary to involve a quantum-mechanical (QM) representation of the reaction center because the molecular mechanics (MM) force fields used for FEP ...

  6. Computational Resource for Drug Discovery - Wikipedia

    en.wikipedia.org/wiki/Computational_Resource_for...

    Computational Resources for Drug Discovery (CRDD) is an important module of the in silico module of Open Source for Drug Discovery (OSDD). [1] The CRDD web portal provides computer resources related to drug discovery , predicting inhibitors, and predicting the ADME-Tox properties of molecules on a single platform.

  7. Schrödinger, Inc. - Wikipedia

    en.wikipedia.org/wiki/Schrödinger,_Inc.

    Schrödinger, Inc. is an international scientific software and biotechnology company that specializes in developing computational tools and software for drug discovery and materials science. Schrödinger's software is used by pharmaceutical companies , biotech firms, and academic researchers to simulate and model the behavior of molecules at ...

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  9. Computational chemistry - Wikipedia

    en.wikipedia.org/wiki/Computational_chemistry

    Quantum computational chemistry addresses these challenges using quantum computing methods, such as qubitization and quantum phase estimation, which are believed to offer scalable solutions. [75] Qubitization involves adapting the Hamiltonian operator for more efficient processing on quantum computers, enhancing the simulation's efficiency.

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