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Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative.It is a first-generation H 1-antihistamine and it works by blocking certain effects of histamine, which produces its antihistamine and sedative effects.
Diphenhydramine is a first-generation antihistamine and an anticholinergic drug. Anticholinergic drugs block the action of acetylcholine , a neurotransmitter in the central nervous system . [ 13 ] Studies propose that long-term use of anticholinergic drugs is associated with an increased risk for dementia among older people.
In 1943, one of his students, Fred Huber, synthesized diphenhydramine. Rieveschl worked with Parke-Davis to test the compound, and the company licensed the patent from him. In 1947 Parke-Davis hired him as their director of research. While he was there, he led the development of a similar drug, orphenadrine. [5]
Phenbenzamine (Antergan) was the first clinically useful antihistamine and was introduced for medical use in 1942. [22] Subsequently, many other antihistamines were developed and marketed. [ 22 ] Diphenhydramine (Benadryl) was synthesized in 1943, tripelennamine (Pyribenzamine) was patented in 1946, and promethazine (Phenergan) was synthesized ...
Wages for people remaining in their jobs increased 4.8% year-on-year, the first rise in 25 months, after gaining 4.7% in October. Annual pay for workers changing jobs climbed 7.2% after rising 6.7 ...
Vicks NyQuil is a brand of over-the-counter medication manufactured by Procter & Gamble intended for the relief of various symptoms of the common cold; the spokesman is Michael Daingerfield of CBS, Global and Nickelodeon fame.
Naloxone is an over-the-counter nasal-spray medication that can save an overdose victim by rapidly reversing the effects of fentanyl, heroin and other opioids. Doctors urge all people ...
BERLIN (Reuters) -Three parties in the eastern German state of Thuringia joined forces on Thursday to keep the poll-topping Alternative for Germany out of power, electing as state premier a ...