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Antagonist and agonist muscles often occur in pairs, called antagonistic pairs. As one muscle contracts, the other relaxes . An example of an antagonistic pair is the biceps and triceps ; to contract, the triceps relaxes while the biceps contracts to lift the arm.
Muscle coactivation occurs when agonist and antagonist muscles (or synergist muscles) surrounding a joint contract simultaneously to provide joint stability, [1] [2] and is suggested to depend crucially on supraspinal processes involved in the control of movement. [3]
Sherrington, one of the founding figures in neurophysiology, observed that when the central nervous system signals an agonist muscle to contract, inhibitory signals are sent to the antagonist muscle, encouraging it to relax and reduce resistance. This mechanism, known as reciprocal inhibition, is essential for efficient movement and helps ...
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what ...
Agonist binding to a receptor can be characterized both in terms of how much physiological response can be triggered (that is, the efficacy) and in terms of the concentration of the agonist that is required to produce the physiological response (often measured as EC 50, the concentration required to produce the half-maximal response). High ...
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Agonist vs. antagonist. In pharmacology the term agonist-antagonist or mixed agonist/antagonist is used to refer to a drug which under some conditions behaves as an agonist (a substance that fully activates the receptor that it binds to) while under other conditions, behaves as an antagonist (a substance that binds to a receptor but does not activate and can block the activity of other agonists).
Physiological antagonism describes the behavior of a substance that produces effects counteracting those of another substance (a result similar to that produced by an antagonist blocking the action of an agonist at the same receptor) using a mechanism that does not involve binding to the same receptor.