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Some of the hoopla around collagen seems founded: There’s evidence that collagen supplements can improve joint pain and functioning, and more limited evidence of its benefits for body ...
Collagen alpha-1(IV) chain (COL4A1) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. [ 5 ] [ 6 ] It is ubiquitously expressed in many tissues and cell types. [ 7 ] COL4A1 is a subunit of the type IV collagen and plays a role in angiogenesis . [ 8 ]
Collagen is also abundant in corneas, blood vessels, the gut, intervertebral discs, and the dentin in teeth. [3] In muscle tissue, it serves as a major component of the endomysium. Collagen constitutes 1% to 2% of muscle tissue and accounts for 6% of the weight to skeletal muscle. [4] The fibroblast is the most common cell creating collagen in ...
[23] [24] This effect may be exaggerated if the increase in arterial stiffness results in reduced wave reflection and more propagation of the pulsatile pressure into the microcirculation. [ 23 ] An increase in arterial stiffness also increases the load on the heart, since it has to perform more work to maintain the stroke volume .
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Type IV collagen is a main component of basement membranes in various tissues (arteries included). [ 13 ] Over the past decade, studies have repeatedly found single-nucleotide polymorphisms located in the collagen ( COL) 4A1 and COL4A2 genes to be associated with cardiovascular disease , and the 13q34 locus harboring these genes is one of the ...
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