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The most common adverse effects include abdominal pain, feeling tired, and vaginal bleeding. [8] Serious side effects may include heavy vaginal bleeding, bacterial infection, and, if pregnant, birth defects. [8] When used, appropriate follow-up care needs to be available. [8] [14] Mifepristone is primarily an antiprogestogen. [8]
Docusate is the common chemical and pharmaceutical name of the anion bis(2-ethylhexyl) sulfosuccinate, also commonly called dioctyl sulfosuccinate (DOSS). [2] [3] [4]Salts of this anion, especially docusate sodium, are widely used in medicine as an emollient laxative and as stool softeners, by mouth or rectally. [1]
Antiglucocorticoid drugs are a class of medications that act to reduce the effects of glucocorticoids, primarily cortisol, in the body. [1] They include direct glucocorticoid receptor antagonists such as mifepristone and synthesis inhibitors such as metyrapone, ketoconazole, and aminoglutethimide. They are used to treat Cushing's syndrome. [2]
Examples include the progesterone receptor weak partial agonist mifepristone, the selective progesterone receptor modulator (SPRM) ulipristal acetate, and the silent antagonist aglepristone. [ 2 ] [ 3 ] In medical abortion , mifepristone is combined with a prostaglandin (e.g., gemeprost ), while ulipristal is used for emergency contraception.
Mifepristone (RU-486; Mifegyne, Mifeprex): An antiprogestogen which is widely used as an abortifacient. Also has antiglucocorticoid and AR antagonist activity. Has been found to produce gynecomastia as a side effect in men at a relatively high rate in clinical studies. Has been studied as a treatment for prostate cancer.
A complex hormonal connection . During menopause, your body and brain undergo some radical shifts that can contribute to the development of an eating disorder.
Water softening is the removal of calcium, magnesium, and certain other metal cations in hard water. The resulting soft water requires less soap for the same cleaning effort, as soap is not wasted bonding with calcium ions. Soft water also extends the lifetime of plumbing by reducing or eliminating scale build-up in pipes
[157] [158] As of 2022, there is no scientifically rigorous evidence that the effects of mifepristone can be reversed this way. [ 159 ] [ 160 ] [ 161 ] Even so, several states in the US require providers of non-surgical abortion who use mifepristone to tell patients that reversal is an option. [ 162 ]
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