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Diosgenin, a phytosteroid sapogenin, is the product of hydrolysis by acids, strong bases, or enzymes of saponins, extracted from the tubers of Dioscorea wild yam species, such as the Kokoro. It is also present in smaller amounts in a number of other species.
However, a number have been identified, including kaempferol, diosgenin (found in yam), apigenin (found in chasteberry), [1] [3] naringenin, and syringic acid, among others. [2] In addition, 3,8-dihydrodiligustilide from Ligusticum chuanxiong is a potent progestogen ( EC 50 = 90 nM), whereas riligustilide is a weak progestogen (EC 50 ≈ 81 μM).
Manufacturing: both bioidentical and non-bioidentical hormones are synthesized using the same chemical precursors; diosgenin is extracted from soy or yam plants, converted into progesterone and used as a hormone chemical precursor to create the final product. [13] "Natural" is also used to promote the idea of being unmodified, and containing ...
Progesterone is used as part of hormone replacement therapy in people who have low progesterone levels, and for other reasons. For purposes of comparison with normal physiological circumstances, luteal phase levels of progesterone are 4 to 30 ng/mL, while follicular phase levels of progesterone are 0.02 to 0.9 ng/mL, menopausal levels are 0.03 to 0.3 ng/mL, and levels of progesterone in men ...
Lawley Pharmaceuticals is a privately owned Australian pharmaceutical company established by pharmacist Michael Buckley in 1995. [1]The company specializes in the manufacture of pharmaceutical-grade hormone replacement therapies and is focused on the development of testosterone and progesterone creams for the treatment of various endocrine deficiencies and medical conditions. [2]
Progesterone is the main female sex hormone that occurs naturally and is also manufactured into a drug that is used in menopausal hormone therapy. [1] Although both classes of hormones can have symptomatic benefit, progestogen is specifically added to estrogen regimens, unless the uterus has been removed, to avoid the increased risk of ...
Examples of progestogens include natural or bioidentical progesterone as well as progestins such as medroxyprogesterone acetate and norethisterone. [ 1 ] Side effects of progestogens include menstrual irregularities , headaches , nausea , breast tenderness , mood changes, acne , increased hair growth , and changes in liver protein production ...
Dioscorea dregeana, the wild yam, is a perennial creeper that is native to the eastern parts of southern Africa. [1] It is commonly used and traded as a traditional medicine, or muti . [ 1 ]
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