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Differentiated adipocytes in a 3T3-L1 cell line stained with Oil Red O. 3T3-L1 is a sub clonal cell line derived from the original 3T3 Swiss albino cell line of 1962. The 3T3 original cell line was isolated from a mouse embryo and propagated for this specific line of 3T3 cells is used to study adipose tissue-related diseases and dysfunctions.
Adiponectin was first characterised in 1995 in differentiating 3T3-L1 adipocytes (Scherer PE et al.). [33] In 1996 it was characterised in mice as the mRNA transcript most highly expressed in adipocytes. [7] In 2007, adiponectin was identified as a transcript highly expressed in preadipocytes [34] (precursors of fat cells) differentiating into ...
In vitro studies on differentiation have used the pre-committed preadipocyte lineage, such as 3T3-L1 and 3T3-F442A cell line, or preadipocytes isolated from the stromal-vascular fraction of white adipose tissue. In vitro differentiation is a highly ordered process. Firstly, proliferating preadipocytes arrest growth usually by contact inhibition.
"Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway". Biochemical and Biophysical Research Communications . 348 (2): 571– 578.
3T3 cells are several cell lines of mouse embryonic fibroblasts. The original 3T3 cell line (3T3-Swiss albino) was established in 1962 by two scientists then at the Department of Pathology in the New York University School of Medicine, George Todaro and Howard Green .
FITM2 has been identified as being overexpressed throughout the time 3T3-L1 (from the adipocyte cell line) is being differentiated which shows resemblance to the peroxisome proliferator-activated receptor gamma at a specific period when lipid droplets have been identified to build-up which results in the adipocyte phenotype that is seen in the ...
Marlean Ames received numerous promotions and good evaluations over the years working in Ohio's youth corrections system, so when she was denied a promotion and demoted in 2019 with a $40,000 pay ...
Chemerin has been implicated in autocrine / paracrine signaling for adipocyte differentiation and also stimulation of lipolysis. [11] [12] Studies with 3T3-L1 cells have shown chemerin expression is low in pre-differentiated adipocytes [11] but its expression and secretion increases both during and after differentiation in vitro.