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Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs inhibit activity of reverse transcriptase , a viral DNA polymerase that is required for replication of HIV and other retroviruses .
Nucleoside reverse transcriptase inhibitor: ... Common side effects include headache, tiredness, trouble sleeping, abdominal pain, weight loss, and rash. [5]
Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) of HIV-1. Tenofovir is a nucleotide reverse transcriptase inhibitor of HIV-1, and it can be classified as an NtRTI. These three drugs work in combination to target the HIV reverse transcriptase protein in three ways, which reduces the virus's capacity to mutate. [5]
Common side effects include headaches, fever, and nausea. [6] Serious side effects include liver problems, muscle damage, and high blood lactate levels. [6] It is commonly used in pregnancy and appears to be safe for the fetus. [6] ZDV is of the nucleoside analog reverse-transcriptase inhibitor (NRTI) class. [6]
Early treatments also required multiple daily pills and often caused harsh side effects. Things started to change in 1995 with combination therapy, which used two nucleoside reverse transcriptase ...
Nucleoside reverse-transcriptase inhibitors (NRTI) and nucleotide reverse-transcriptase inhibitors (NtRTI) are nucleoside and nucleotide analogues which inhibit reverse transcription. HIV is an RNA virus, so it can not be integrated into the DNA in the nucleus of the human cell unless it is first "reverse" transcribed into DNA.
Severe side effects include high blood lactate and an enlarged liver. [4] There are no absolute contraindications. [4] It is often recommended during pregnancy and appears to be safe. [4] It is a nucleotide reverse transcriptase inhibitor and works by decreasing the ability of the viruses to replicate. [4]
Lactic acidosis (excess lactic acid in blood) is a rare and potentially fatal side effect. It is characterized by the following symptoms: deep and rapid breathing, tiredness or weakness, nausea, vomiting, abnormal muscle pain, dizziness or drowsiness
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