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Haematin (also known as hematin, ferriheme, hematosin, hydroxyhemin, oxyheme, phenodin, or oxyhemochromogen) is a dark bluish or brownish pigment containing iron in the ferric state, obtained by the oxidation of haem. [1] Haematin inhibits the synthesis of porphyrin (by repressing ALAS1 synthesis), [2] and stimulates the synthesis of globin.
In acidic solutions, complexes of hematein with metals (usually aluminium or iron, but also chromium, zirconium and several others) are used as biological stains. Aluminium-haematein (haemalum) is the "routine" stain for cell nuclei in sections of human and other animal tissues.
Hemin is protoporphyrin IX containing a ferric iron (Fe 3+) ion with a coordinating chloride ligand.. Chemically, hemin differs from the related heme-compound hematin chiefly in that the coordinating ion is a chloride ion in hemin, whereas the coordinating ion is a hydroxide ion in hematin. [2]
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The following other wikis use this file: Usage on de.wikipedia.org Hämatine; Usage on es.wikipedia.org Hematina; Usage on fa.wikipedia.org هماتین
A hematinic is a nutrient required for the formation of blood cells in the process of hematopoiesis. [1] The main hematinics are iron, Vitamin B 12, and folate. [2] Deficiency in hematinics can lead to anaemia.
Free heme is toxic to cells, so the parasites convert it into an insoluble crystalline form called hemozoin. In malaria parasites, hemozoin is often called malaria pigment . Since the formation of hemozoin is essential to the survival of these parasites, it is an attractive target for developing drugs and is much-studied in Plasmodium as a way ...
Heme arginate (or haem arginate) is a compound of heme and arginine used in the treatment of acute porphyrias. [1] [2] This heme product is only available outside the United States and is equivalent to hematin.