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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution; although, only in a few cases are genes the primary cause of obesity.
Fat mass and obesity-associated protein, also known as alpha-ketoglutarate-dependent dioxygenase FTO, is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first messenger RNA (mRNA) demethylase that has been identified. [ 5 ]
While it may not seem obvious at first, the obesity epidemic and economics have a direct connection to each other, especially when it comes to spending categories like healthcare, food, and fitness.
Obesity has been observed throughout human history. Many early depictions of the human form in art and sculpture appear obese. [2] However, it was not until the 20th century that obesity became common — so much so that, in 1997, the World Health Organization (WHO) formally recognized obesity as a global epidemic [3] and estimated that the worldwide prevalence of obesity has nearly tripled ...
A new study published Friday in the journal, JAMA Health Forum, found that obesity numbers ticked down slightly from 46% in 2022 to 45.6% in 2023. While only a slight decline, this is the first ...
Obesity caused by the American lifestyle of moving less and eating more is a prime factor contributing to Type 2 diabetes. In the United States, 38.4 million people have diabetes, and 95% are Type ...
Monogenic obesity is excess weight caused by a mutation in a single gene, as opposed to syndromic obesity not tied to a single gene variation and most obesity, which is caused by multiple genetic and environmental risk factors. Monogenetic obesity mostly affects the hypothalamus and leptin–melanocortin system (see hypothalamic obesity ...
Symptoms of Obesity. Obesity symptoms can differ greatly from one person to another. But most symptoms show up because bodily systems have to work harder due to the excess weight.