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2. File:Lac operon.pdf - Wikipedia

   en.wikipedia.org/wiki/File:Lac_operon.pdf

   You are free: to share – to copy, distribute and transmit the work; to remix – to adapt the work; Under the following conditions: attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made.

3. lac operon - Wikipedia

   en.wikipedia.org/wiki/Lac_operon

   The lactose operon (lac operon) is an operon required for the transport and metabolism of lactose in E. coli and many other enteric bacteria.Although glucose is the preferred carbon source for most enteric bacteria, the lac operon allows for the effective digestion of lactose when glucose is not available through the activity of β-galactosidase. [1]

4. Diauxic growth - Wikipedia

   en.wikipedia.org/wiki/Diauxic_growth

   Monod later put aside his work on diauxic growth and focused on the lac operon model of gene expression, which led to a Nobel prize. Diauxie occurs because organisms use operons or multiple sets of genes to control differently the expression of enzymes needed to metabolize the different nutrients or sugars they encounter. If an organism ...

5. Synthetic biological circuit - Wikipedia

   en.wikipedia.org/wiki/Synthetic_biological_circuit

   They discovered that the mechanism that controlled the metabolic "switching" function was a two-part control mechanism on the lac operon. When lactose is present in the cell the enzyme β-galactosidase is produced to convert lactose into glucose or galactose. When lactose is absent in the cell the lac repressor inhibits the production of the ...

6. Catabolite repression - Wikipedia

   en.wikipedia.org/wiki/Catabolite_repression

   Absence of glucose will "turn off" catabolite repression. When glucose levels are low, the phosphorylated form of EIIA accumulates and consequently activates the enzyme adenylyl cyclase, which will produce high levels of cAMP. cAMP binds to catabolite activator protein (CAP) and together they will bind to a promoter sequence on the lac operon ...

7. Cis-regulatory element - Wikipedia

   en.wikipedia.org/wiki/Cis-regulatory_element

   An example of a cis-acting regulatory sequence is the operator in the lac operon. This DNA sequence is bound by the lac repressor, which, in turn, prevents transcription of the adjacent genes on the same DNA molecule. The lac operator is, thus, considered to "act in cis" on the regulation of the nearby genes.

8. Silencer (genetics) - Wikipedia

   en.wikipedia.org/wiki/Silencer_(genetics)

   The lac operon in the prokaryote E. coli consists of genes that produce enzymes to break down lactose. Its operon is an example of a prokaryotic silencer. The three functional genes in this operon are lacZ, lacY, and lacA. [6] The repressor gene, lacI, will produce the repressor protein LacI which is under allosteric regulation.

9. Promoter (genetics) - Wikipedia

   en.wikipedia.org/wiki/Promoter_(genetics)

   When referring to a promoter some authors actually mean promoter + operator; i.e., the lac promoter is IPTG inducible, meaning that besides the lac promoter, the lac operon is also present. If the lac operator were not present the IPTG would not have an inducible effect. [citation needed] Another example is the Tac-Promoter system (Ptac ...