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It is a form of penicillin which is a salt of benzylpenicillin and the local anaesthetic agent procaine. [9] The salt has weak solubility, and is prepared as a suspension. Upon injection it forms a deposit within tissue (a "depot'), and the salt slowly dissolves into interstitial fluid - dissociating the two molecules into their bioactive forms over an extended pe
Two long-acting forms benzathine benzylpenicillin and procaine benzylpenicillin are available for use by injection into a muscle only. [6] Side effects include diarrhea, seizures, and allergic reactions including anaphylaxis. [6] When used to treat syphilis or Lyme disease a reaction known as Jarisch–Herxheimer may occur. [6]
The side effects of penicillin are bodily responses to penicillin and closely related antibiotics that do not relate directly to its effect on bacteria. A side effect is an effect that is not intended with normal dosing. [1] Some of these reactions are visible and some occur in the body's organs or blood.
It can be formulated as an insoluble salt, and there are two such formulations in current use: procaine penicillin and benzathine benzylpenicillin. When a high concentration in the blood must be maintained, penicillin G must be administered at relatively frequent intervals, because it is eliminated quite rapidly from the bloodstream by the kidney.
The β-lactam core structures. (A) A penam.(B) A carbapenam.(C) An oxapenam.(D) A penem.(E) A carbapenem.(F) A monobactam.(G) A cephem.(H) A carbacephem.(I) An oxacephem. This is a list of common β-lactam antibiotics—both administered drugs and those not in clinical use—organized by structural class.
Benzathine benzylpenicillin/procaine benzylpenicillin, sold under the brand name Bicillin C-R, is an antibiotic medication. [1] It contains the antibiotics benzathine benzylpenicillin (penicillin G benzathine) and procaine benzylpenicillin (penicillin G procaine).
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β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.