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The kidneys are responsible for converting 25-hydroxyvitamin D to 1,25-hydroxyvitamin D. This is the active form of vitamin D in the body. Kidney disease reduces 1,25-hydroxyvitamin D formation, leading to a deficiency of the effects of vitamin D. [1]
When this molecule is exposed to UVB light from the sun it absorbs the energy in the process of being conveted to vitamin D. The function was to prevent DNA damage, the vitamin molecule at this time being an end product without function. Present day, phytoplankton in the ocean photosynthesize vitamin D without any calcium management function.
The conversion of 25(OH) vitamin D to 1,25(OH)2 vitamin D is impaired, reducing intestinal calcium absorption and increasing PTH. [2] The kidney fails to respond adequately to PTH, which normally promotes phosphaturia and calcium reabsorption, or to FGF-23, which also enhances phosphate excretion. [2]
Vitamin D influences a lot of cellular functions in the body—so it’s possible that mild deficiencies can impact the development of aging-related brain changes, says David Merrill, MD, PhD, a ...
The body produces vitamin D as a response to sun exposure. Certain foods and supplements can also boost vitamin D intake. Despite its name, vitamin D is not a vitamin but a hormone or prohormone.
Vitamin D deficiency can occur. Vitamin D binding protein is lost. Hypocalcaemia: lack of 25-hydroxycholecalciferol (the way that vitamin D is stored in the body). As vitamin D regulates the amount of calcium present in the blood, a decrease in its concentration will lead to a decrease in blood calcium levels. It may be significant enough to ...
Vitamin D supplements are linked to many health benefits, including decreasing the chance of heart disease, supporting immune function, and aiding weight loss. New research suggests that calcium ...
An excess of vitamin D causes abnormally high blood concentrations of calcium, which can cause overcalcification of the bones, soft tissues, heart and kidneys. In addition, hypertension can result. [2] Symptoms of vitamin D toxicity may include the following: Dehydration; Vomiting; Diarrhea; Decreased appetite; Irritability; Constipation ...
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