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Adapalene, sold under the brand name Differin among others, is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. [6]
Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves. [6]The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied; [7] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).
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The Rocky Mountaineer and Royal Canadian Pacific provide luxury rail tours for viewing scenery in the Canadian Rockies as well as other mountainous areas of British Columbia and Alberta. Canada has 49,422 kilometres (30,709 mi) total trackage, of which only 129 kilometres (80 mi) is electrified (all urban rail transit networks).
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