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SGLT proteins utilize this sodium gradient to transport glucose across the apical membrane into the cell, even against the glucose concentration gradient. [ 11 ] [ 3 ] This mechanism is an example of secondary active transport.
SGLT2 is a member of the sodium glucose cotransporter family, which are sodium-dependent glucose transport proteins. SGLT2 is the major cotransporter involved in glucose reabsorption in the kidney. [6] SGLT2 is located in the early proximal tubule, and is responsible for reabsorption of 80-90% of the glucose filtered by the kidney glomerulus. [7]
Glucose transporters are integral membrane proteins that mediate the transport of glucose and structurally related substances across cellular membranes.Two families of glucose transporter have been identified: the facilitated diffusion glucose transporter family (GLUT family), also known as uniporters, and the sodium-dependent glucose transporter family (SGLT family), also known as ...
Sodium-glucose transport protein 2 (SGLT2) inhibitors. DepositPhotos.com. Insulin Resistance Prevention Tips.
SGLT2 is the major transport protein and promotes reabsorption from the glomerular filtration glucose back into circulation and is responsible for approximately 90% of the kidney's glucose reabsorption. [1] SGLT2 is mainly expressed in the kidneys on the epithelial cells lining the first segment
GLUTs are integral membrane proteins that contain 12 membrane-spanning helices with both the amino and carboxyl termini exposed on the cytoplasmic side of the plasma membrane. GLUT proteins transport glucose and related hexoses according to a model of alternate conformation, [ 5 ] [ 6 ] [ 7 ] which predicts that the transporter exposes a single ...
Cells also contain anion antiporters such as the Band 3 (or AE1) anion transport protein. This cotransporter is an important integral protein in mammalian erythrocytes and moves chloride ion and bicarbonate ion in a one-to-one ratio across the plasma membrane based only on the concentration gradient of the two ions.
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