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13627 Ensembl ENSG00000156508 ENSMUSG00000037742 UniProt P68104 P10126 RefSeq (mRNA) NM_001402 NM_001403 NM_010106 RefSeq (protein) NP_001393 NP_034236 Location (UCSC) Chr 6: 73.49 – 73.53 Mb Chr 9: 78.39 – 78.4 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Elongation factor 1-alpha 1 (eEF1a1) is a translation elongation protein, expressed across eukaryotes. In humans, it is ...
The eIF2 alpha subunit is characterized by an OB-fold domain and two beta strands. This subunit helps to regulate translation, as it becomes phosphorylated to inhibit protein synthesis. [2] The eIF4F complex supports the cap-dependent translation initiation process and is composed of the initiation factors eIF4A, eIF4E, and eIF4G.
Animal Farm is a satirical allegorical novella, in the form of a beast fable, [1] by George Orwell, first published in England on 17 August 1945. [ 2 ] [ 3 ] It tells the story of a group of anthropomorphic farm animals who rebel against their human farmer, hoping to create a society where the animals can be equal, free, and happy.
Overview of eukaryotic messenger RNA (mRNA) translation Translation of mRNA and ribosomal protein synthesis Initiation and elongation stages of translation involving RNA nucleobases, the ribosome, transfer RNA, and amino acids The three phases of translation: (1) in initiation, the small ribosomal subunit binds to the RNA strand and the initiator tRNA–amino acid complex binds to the start ...
Translation is one of the key energy consumers in cells, hence it is strictly regulated. Numerous mechanisms have evolved that control and regulate translation in eukaryotes as well as prokaryotes. Regulation of translation can impact the global rate of protein synthesis which is closely coupled to the metabolic and proliferative state of a cell.
eIF4G is a 175.5-kDa scaffolding protein that interacts with eIF3 and the Poly(A)-binding protein (PABP), as well as the other members of the eIF4F complex. eIF4E recognizes and binds to the 5' cap structure of mRNA, while eIF4G binds PABP, which binds the poly(A) tail, potentially circularizing and activating the bound mRNA. eIF4A – a DEAD ...
Translation can be downregulated by miRNAs (microRNAs). These RNA strands can cleave mRNA strands they are complementary to and will thus stop translation. [15] Translation can also be regulated via helper proteins. For example, a protein called eukaryotic initiation factor-2 can bind to the smaller subunit of the ribosome, starting translation.
A bacterial initiation factor (IF) is a protein that stabilizes the initiation complex for polypeptide translation. Translation initiation is essential to protein synthesis and regulates mRNA translation fidelity and efficiency in bacteria. [1] The 30S ribosomal subunit, initiator tRNA, and mRNA form an initiation complex for elongation. [2]