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Basophilic stippling, also known as punctate basophilia, is the presence of numerous basophilic granules that are dispersed through the cytoplasm of erythrocytes in a peripheral blood smear. They can be demonstrated to be RNA .
Features of poisoning differ depending on whether the agent is an organic compound (one that contains carbon), or an inorganic one. [29] Organic lead poisoning is now very rare, because countries across the world have phased out the use of organic lead compounds as gasoline additives, but such compounds are still used in industrial settings. [29]
A cell containing Pappenheimer bodies is a siderocyte. Reticulocytes often contain Pappenheimer bodies. They are mostly observed in diseases such as myelodysplastic syndrome (MDS), sideroblastic anemia, hemolytic anemia, lead poisoning and sickle cell disease. They can interfere with platelet counts when the analysis is performed by electro ...
Basophilic stippling is one morphologic finding of thalassemia which does not appear in iron deficiency or anemia of chronic disease. The patient should be in an ethnically at-risk group and the diagnosis is not confirmed without a confirmatory method such as hemoglobin HPLC, H body staining, molecular testing or another reliable method.
With lead poisoning, see coarse basophilic stippling of red blood cells on peripheral blood smear; Specific test: Prussian blue stain of RBC in marrow shows ringed sideroblasts. Prussian blue staining involves a non-enzymatic reaction of ferrous iron with ferrocyanide forming ferric-ferrocyanide, which is blue in color.
Lead poisoning is most commonly caused by breathing in lead dust or particles, but it can also occur by touching a surface where lead is present, then touching one’s nose or mouth, ...
Lead poisoning occurs when lead builds up in the body, often over months or years, according to Mayo Clinic, and even small amounts can cause issues. It's common in adults who do home renovations ...
However, other research has shown that there has been stippling found in normal blood cells as well. Stippling is supposed to be one of the earliest symptoms of lead poisoning, although most scientists now regard it as a degenerative condition, along with polychromasia. [citation needed]