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Enzyme induction is a process in which a molecule (e.g. a drug) induces (i.e. initiates or enhances) the expression of an enzyme. Enzyme inhibition can refer to the inhibition of the expression of the enzyme by another molecule; interference at the enzyme-level, basically with how the enzyme works.
An enzyme inducer is a type of drug that increases the metabolic activity of an enzyme either by binding to the enzyme and activating it, or by increasing the expression of the gene coding for the enzyme. [1] [page needed] It is the opposite of an enzyme repressor.
Enzyme induction is a process in which a molecule (e.g., a drug) induces (i.e., initiates or enhances) the expression of an enzyme. The induction of heat shock proteins in the fruit fly Drosophila melanogaster. The Lac operon is an interesting example of how gene expression can be regulated.
Induction or inhibition of these enzymes can cause drug interactions. [94] Enzyme levels can also be regulated by changing the rate of enzyme degradation. [1]: 30.1.1 The opposite of enzyme induction is enzyme repression.
Induction (play), an opening scene; Induction (teachers), support of novice teachers; Inductive reasoning aptitude; Collective Induction, in psychology; Hypnotic induction, causing hypnosis "Induction", a song by Broken Spindles from Fulfilled/complete "Induction" (short story), a short story by Greg Egan
Melvin Cohn in Monod's lab at the Pasteur Institute then found that β-galactosides induced enzyme activity. The idea of enzyme adaptation was thus replaced with the concept of enzyme induction, in which a molecule induces expression of a gene or operon, often by binding to a repressor protein and preventing it from attaching to the operator. [2]
This enzyme induction can be initiated by many natural or synthetic compounds, e.g., carcinogenic polycyclic hydrocarbons such as benzopyrene, [17] several natural compounds, [10] and dioxins. [1] Secondly, AH receptors are involved in the activation or silencing of genes that lead to the toxic effects of high doses of dioxins. [1]
Indoleamine 2,3-dioxygenase is the first and rate-limiting enzyme of tryptophan catabolism through the kynurenine pathway. IDO is an important molecule in the mechanisms of tolerance and its physiological functions include the suppression of potentially dangerous inflammatory processes in the body. [ 16 ]