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Irinotecan is a hydrophilic compound with a large volume of distribution (400 L/m 2). [20] [21] At physiological pH, irinotecan and its active metabolite ethyl-10-hydroxy-camptothecin (SN-38) are present in two pH-dependent equilibrium isoforms; the anti tumor active lactone ring which hydrolyzed to the carboxylate isoform. [21]
It is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold.
Postterm pregnancy, i.e. if the pregnancy has gone past the end of the 42nd week. Intrauterine fetal growth restriction. There are health risks to the woman in continuing the pregnancy (e.g. pre-eclampsia). Premature rupture of the membranes); this is when the membranes have ruptured, but labor does not start within a specific amount of time. [3]
FOLFIRI is a chemotherapy regimen for treatment of colorectal cancer.It is made up of the following drugs: [1] FOL – folinic acid (), a vitamin B derivative with multiple applications, which in this context decreases the cytotoxicity of 5-fluorouracil;
Etirinotecan pegol (trade name Onzeald) is a drug developed by Nektar Therapeutics for the treatment of certain kinds of breast cancer with brain metastases.The European Medicines Agency refused to grant it a marketing authorisation in 2017.
Hamdard Laboratories produces more than six hundred (600) Herbal Products. [1]Hamdard has a full range of medicines for digestive disorders of stomach and intestine, abdominal cramps, hyper-acidity etc., anemia, jaundice, purification of blood from impurities, liver ailments, female ailments like leucorrhoea, menstrual irregularities and for protection of pregnancy.
Topotecan is a semi-synthetic derivative of camptothecin.Camptothecin is a natural product extracted from the bark of the tree Camptotheca acuminata.Topoisomerase-I is a nuclear enzyme that relieves torsional strain in DNA by opening single strand breaks. [20]
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