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Pneumocystis pneumonia (PCP), also known as Pneumocystis jirovecii pneumonia (PJP), is a form of pneumonia that is caused by the yeast-like fungus Pneumocystis jirovecii. [ 3 ] [ 4 ] Pneumocystis specimens are commonly found in the lungs of healthy people although it is usually not a cause for disease. [ 5 ]
to diagnose or manage asthma [5] [6] [7] to detect respiratory disease in patients presenting with symptoms of breathlessness, and to distinguish respiratory from cardiac disease as the cause [8] to measure bronchial responsiveness in patients suspected of having asthma [8]
The prevalence of childhood asthma in the United States has increased since 1980, especially in younger children. Rates of asthma have increased significantly between the 1960s and 2008 [9] [10] with it being recognized as a major public health problem since the 1970s. [5] Some 9% of US children had asthma in 2001, compared with just 3.6% in 1980.
Pneumocystis pneumonia is an important disease of immunocompromised humans, particularly patients with HIV, but also patients with an immune system that is severely suppressed for other reasons, for example, following a bone marrow transplant. In humans with a normal immune system, it is an extremely common silent infection. [4]
The fundamental problem in asthma appears to be immunological: young children in the early stages of asthma show signs of excessive inflammation in their airways. Epidemiological findings give clues as to the pathogenesis : the incidence of asthma seems to be increasing worldwide, and asthma is now very much more common in affluent countries.
Asthma phenotyping and endotyping has emerged as a novel approach to asthma classification inspired by precision medicine which separates the clinical presentations of asthma, or asthma phenotypes, from their underlying causes, or asthma endotypes. The best-supported endotypic distinction is the type 2-high/type 2-low distinction.
Bronchiolitis obliterans results in worsening shortness of breath, wheezing, and a dry cough.The symptoms can start gradually, or severe symptoms can occur suddenly. [9] [10] These symptoms represent an obstructive pattern that is non-reversible with bronchodilator therapy, and need to be related to various lung insults. [11]
According to the Mayo Clinic, “Allergy symptoms, which depend on the substance involved, can affect your airways, sinuses and nasal passages, skin, and digestive system.” [5] The severity of the following symptoms varies from child to child. [5] The symptoms of indoor and outdoor allergies in children may include: [18] [19] Runny nose
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