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Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of the cell. Ferroportin is the only known iron exporter. [6] After dietary iron is absorbed into the cells of the small intestine, ferroportin allows that iron to be transported out of those cells and into the bloodstream.
Ferroportin is upregulated in the reticuloendothelial macrophages after phagocytosis occurs so that iron from the degraded red blood cells can be released into the bloodstream and transported to other types of cells as needed. Hepcidin, a protein synthesized in the liver in response to iron or inflammation, is a regulator of ferroportin ...
Export occurs through ferroportin, often aided by hephaestin (Hp) and/or ceruloplasmin (Cp), and repressed by hepcidin. Human iron metabolism is the set of chemical reactions that maintain human homeostasis of iron at the systemic and cellular level.
The remaining syllables of the INNs, as well as the column Source, are explained in Nomenclature of monoclonal antibodies. Types of monoclonal antibodies with other structures than naturally occurring antibodies. The abbreviations in the column Type are as follows: mab: whole monoclonal antibody; Fab: fragment, antigen-binding (one arm)
Iron overload (also known as haemochromatosis or hemochromatosis) is the abnormal and increased accumulation of total iron in the body, leading to organ damage. [1] The primary mechanism of organ damage is oxidative stress, as elevated intracellular iron levels increase free radical formation via the Fenton reaction.
A blizzard warning goes into effect when an area is expected to see frequent wind gusts over 35 mph as well as significantly reduced visibility from snow. / Credit: CBS News
Bantu siderosis, is the genetic side of the disorder. Some African people carry a unique ferroportin mutation that predisposes them to iron overload, making it a kind of ferroportin disease . [ 4 ] [ 5 ] African-Americans, who have no exposure to iron-rich beer, can also exhibit this issue.
Where will Brood XIV cicadas emerge? Known as the "Great(er) Eastern Brood," this group is historically found in areas of north Georgia, Kentucky, Tennessee, southern Indiana and Ohio, North ...