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Bile ducts: 2. Intrahepatic bile ducts 3. Left and right hepatic ducts 4. Common hepatic duct 5. Cystic duct 6. Common bile duct 7. Ampulla of Vater 8. Major duodenal papilla 9. Gallbladder 10–11. Right and left lobes of liver 12. Spleen 13. Esophagus 14. Stomach 15. Pancreas: 16.
Weight loss; Pruritus ... life the ductal plates are remodeled. The malformations can be atretic or fibrocystic. Atretic causes. Intrahepatic bile duct ...
The bile duct [1] [4] (formerly known as the common bile duct [4]) is a part of the biliary tract. [4] It is formed by the union of the common hepatic duct and cystic duct. It ends by uniting with the pancreatic duct to form the hepatopancreatic ampulla. It possesses its sphincter to enable the regulation of bile flow.
The bile duct scarring that occurs in PSC narrows the ducts of the biliary tree and impedes the flow of bile to the intestines. Eventually, it can lead to cirrhosis of the liver and liver failure . PSC increases the risk of various cancers, including liver cancer , gallbladder carcinoma , colorectal cancer , and cholangiocarcinoma .
Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune disease of the liver. [1] [2] [3] It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up in the liver, a condition called cholestasis.
When the intrahepatic bile duct wall has protrusions, it is clearly seen as central dots or a linear streak. [10] Caroli disease is commonly diagnosed after this “central dot sign” is detected on a CT scan or ultrasound. [10] However, cholangiography is the best, and final, approach to show the enlarged bile ducts as a result of Caroli disease.
Progressive familial intrahepatic cholestasis (PFIC) is a group of familial cholestatic conditions caused by defects in biliary epithelial transporters. The clinical presentation usually occurs first in childhood with progressive cholestasis .
The severity of the disorder can vary within the same family, with symptoms ranging from so mild as to go unnoticed, to severe heart and/or liver disease that requires transplantation. [6] It is uncommon, but Alagille syndrome can be a life-threatening disease with a mortality rate of 10%. [7]