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4,7-Dichloroquinoline was first reported in a patent filed by IG Farben in 1937. [2] However, its synthesis was not investigated in detail until chloroquine was developed as an antimalarial drug. [ 3 ] : 130–132 A route to the intermediate starting from 3-chloroaniline was developed by chemists at Winthrop Chemical Co .
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[1] [4] Chloroquine is a member of the drug class 4-aminoquinoline. [1] As an antimalarial, it works against the asexual form of the malaria parasite in the stage of its life cycle within the red blood cell. [1] How it works in rheumatoid arthritis and lupus erythematosus is unclear. [1] Chloroquine was discovered in 1934 by Hans Andersag.
24/7 Help. For premium support please call: 800-290-4726 more ways to reach us. Mail. Sign in. ... The universal product code (UPC) is 4061459337471, according to a news release from Aldi.
An example is the synthesis of 4,7-dichloroquinoline. [7] Floctafenine and glafenine are a pair of fenamate NSAIDs whose syntheses rely on the Gould–Jacobs reaction. [8] Several quinolone antibiotic structures such as rosoxacin, oxolinic acid, droxacin, etc. Another example is in the synthesis of antimalarials as aminoalkylamino derivatives ...