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Clark's rule. Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [ 1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK ...
The lateral surface of a right cylinder is the meeting of the generatrices. [3] It can be obtained by the product between the length of the circumference of the base and the height of the cylinder. Therefore, the lateral surface area is given by: =. [2] Where: represents the lateral surface area of the cylinder; is approximately 3.14;
Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five ( RO5 ), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans.
Body surface area. In physiology and medicine, the body surface area ( BSA) is the measured or calculated surface area of a human body. For many clinical purposes, BSA is a better indicator of metabolic mass than body weight because it is less affected by abnormal adipose mass. Nevertheless, there have been several important critiques of the ...
In the field of pharmacokinetics, the area under the curve ( AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography–mass spectrometry [ 1] ). In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is ...
A tablet (also known as a pill) is a pharmaceutical oral dosage form ( oral solid dosage, or OSD) or solid unit dosage form. Tablets may be defined as the solid unit dosage form of medication with suitable excipients. It comprises a mixture of active substances and excipients, usually in powder form, that are pressed or compacted into a solid dose.
Pharmacokinetics is based on mathematical modeling that places great emphasis on the relationship between drug plasma concentration and the time elapsed since the drug's administration. Pharmacokinetics is the study of how an organism affects the drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism.
In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. [ 1 ] A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life .