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Like insulin, sulfonylureas can induce weight gain, mainly as a result of their effect to increase insulin levels and thus use of glucose and other metabolic fuels. Other side-effects are: gastrointestinal upset, headache and hypersensitivity reactions. The safety of sulfonylurea therapy in pregnancy is unestablished.
They work best with patients over 40 years old who have had diabetes mellitus for under ten years. They cannot be used with type 1 diabetes, or diabetes of pregnancy. They can be safely used with metformin or glitazones. The primary side-effect is hypoglycemia, which appears to happen more commonly with sulfonylureas than with other treatments ...
Because weight loss is a “side effect” of the diabetes drug, ... Look out for the common side effects of metformin, which include: Indigestion. Nausea. Vomiting. ... People on sulfonylureas ...
Metformin is more commonly associated with gastrointestinal adverse effects than most other antidiabetic medications. [46] [76] The most serious potential adverse effect of metformin is lactic acidosis; this complication is rare, and seems to be related to impaired liver or kidney function.
Prepare for potential side effects. Taking metformin may cause unpleasant side effects like diarrhea, nausea, and an upset stomach. Taking it with food can reduce the risk.
One theory is that metformin has anti-tumor side effects because it lowers insulin levels and keeps tumor cells from multiplying. Still, more research is needed. Inside Creative House/istockphoto
Glimepiride is an antidiabetic medication within the sulfonylurea class, primarily prescribed for the management of type 2 diabetes. [1] [2] It is regarded as a second-line option compared to metformin, due to metformin's well-established safety and efficacy. [1]
Side effect may include low blood sugar, vomiting, abdominal pain, rash, and liver problems. [4] [7] Use by those with significant kidney problems or liver problems or who are pregnant is not recommended. [7] [4] Gliclazide is in the sulfonylurea family of medications. [7] It works mostly by increasing the release of insulin. [7]
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