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The disease is most common in tropical areas of the world but may occur anywhere. [7] Outbreaks may arise after heavy rainfall. [7] The disease was first described by physician Adolf Weil in 1886 in Germany. [17] [18] Infected animals may have no, mild or severe symptoms. [19] These may vary by the type of animal.
ISBN 978-0-87553-189-2; Red Book: 2009 Report of the Committee on Infectious Diseases. 2009. American Academy of Pediatrics. 28th ed. ISBN 978-1-58110-306-9; Centers for Disease Control and Prevention. CDC Works 24/7. Retrieved on August 4, 2009.
Name First elements Short description OEIS Mersenne prime exponents : 2, 3, 5, 7, 13, 17, 19, 31, 61, 89, ... Primes p such that 2 p − 1 is prime.: A000043 ...
An etiological agent of disease may require an independent co-factor, and be subject to a promoter (increases expression) to cause disease. An example of all the above, which was recognized late, is that peptic ulcer disease may be induced by stress, requires the presence of acid secretion in the stomach, and has primary etiology in ...
The disease tended to occur in summer and early autumn. Thomas Forestier, a physician during the first outbreak, provided a written account of his own experiences with the sweating sickness in 1485. [4] Forestier put great emphasis on the sudden breathlessness commonly associated with the final hours of sufferers. [4]
It has long been suspected as a causative agent in Crohn's disease in humans, [4] [5] but studies have been unable to show definite correlation. [6] One study has argued that the presence of antibodies against Mycobacterium avium subspecies paratuberculosis is associated with increased propensity of patients with Crohn's disease to receive ...
[2] [3] Typically, the term pathogen is used to describe an infectious microorganism or agent, such as a virus, bacterium, protozoan, prion, viroid, or fungus. [4] [5] [6] Small animals, such as helminths and insects, can also cause or transmit disease. However, these animals are usually referred to as parasites rather than pathogens. [7]
Nonetheless, Koch was already aware that the causative agent of cholera, Vibrio cholerae, could be found in both sick and healthy people, invalidating his first postulate. [ 6 ] [ 9 ] Since the 1950s, Koch's postulates have been treated as obsolete for epidemiology research, but they are still taught to emphasize historical approaches to ...