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Neurology. Chemotherapy-induced peripheral neuropathy (CIPN) is a nerve -damaging side effect of antineoplastic agents in the common cancer treatment, chemotherapy. [1] CIPN afflicts between 30% and 40% of patients undergoing chemotherapy. Antineoplastic agents in chemotherapy are designed to eliminate rapidly dividing cancer cells, but they ...
Vincristine-induced neuropathy is the main dose-limiting side effect. [10] Chemotherapy-induced peripheral neuropathy can be severe, and may be a reason to reduce or avoid using vincristine. The symptoms are progressive and enduring tingling numbness, pain and hypersensitivity to cold, beginning in the hands and feet and sometimes affecting the ...
Potential side effects of chemotherapy include: Fatigue. Hair loss. Nausea and vomiting. ... Peripheral neuropathy (numbness or tingling in hands, arms, feet, legs) Hair or nail changes.
4.1%-12.4% (12-month prevalence, US adults) [1] Neuropathic pain is pain caused by a lesion or disease of the somatosensory nervous system. [2][3] Neuropathic pain may be associated with abnormal sensations called dysesthesia or pain from normally non-painful stimuli (allodynia). It may have continuous and/or episodic (paroxysmal) components.
The systems of the body most affected by chemotherapy drugs include visual and semantic memory, attention and motor coordination and executive functioning. [9] [10] These effects can impair a chemotherapy patient's ability to understand and make decisions regarding treatment, perform in school or employment and can reduce quality of life. [10]
Vinorelbine has a number of side-effects that can limit its use: Chemotherapy-induced peripheral neuropathy (a progressive, enduring and often irreversible tingling numbness, intense pain, and hypersensitivity to cold, beginning in the hands and feet and sometimes involving the arms and legs [12]), lowered resistance to infection, bruising or bleeding, anaemia, constipation, vomitings ...
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