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[1] The meaning of "gold standard" may differ between practical medicine and the statistical ideal. With some medical conditions, only an autopsy can guarantee diagnostic certainty. In these cases, the gold standard test is the best test that keeps the patient alive, and even gold standard tests can require follow-up to confirm or refute the ...
The positive predictive value (PPV), or precision, is defined as = + = where a "true positive" is the event that the test makes a positive prediction, and the subject has a positive result under the gold standard, and a "false positive" is the event that the test makes a positive prediction, and the subject has a negative result under the gold standard.
[1] [2] In clinical practice, verification bias is more likely to occur when a preliminary diagnostic test is negative. Because many gold standard tests can be invasive, expensive, and carry a higher risk (e.g. angiography, biopsy, surgery), patients and physicians may be more reluctant to undergo further work-up if a preliminary test is negative.
However, electron microscopy is highly versatile due to its ability to analyze any type of sample and identify any type of virus. Therefore, it remains the gold standard for identifying viruses that do not show up on routine diagnostic tests or for which routine tests present conflicting results. [7]
Gold standard may also refer to: Gold Standard issue, series of postage stamps issued by the Soviet Union between 1923 and 1927; Gold standard (test), the diagnostic test that is the best available under reasonable conditions; Gold Standard (carbon offset standard), widely accepted standard for evaluating the value of carbon offsets
The diagnostic odds ratio ranges from zero to infinity, although for useful tests it is greater than one, and higher diagnostic odds ratios are indicative of better test performance. [1] Diagnostic odds ratios less than one indicate that the test can be improved by simply inverting the outcome of the test – the test is in the wrong direction ...
With confirmatory Western blot, the chance of a false-positive identification in a low-prevalence setting is about 1 in 250 000 (95% CI, 1 in 173 000 to 1 in 379 000). The specificity rate given here for the inexpensive enzyme immunoassay screening tests indicates that, in 1,000 HIV test results of healthy individuals, about 15 of these results ...
A Strategic Group of Experts on In Vitro Diagnostics (SAGE IVD) is appointed by the WHO to advise on its development as it is regularly reviewed and expanded. [8] Different countries can adapt it; the Indian Council of Medical Research produced its own version of the EDL in 2019, a year after the first edition.