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Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, [1] seen in diseases such as pemphigus vulgaris. [2] It is absent in bullous pemphigoid , making it useful for differential diagnosis .
The McGill Pain Questionnaire, also known as McGill Pain Index, is a scale of rating pain developed at McGill University by Melzack and Torgerson in 1971. [1] It is a self-report questionnaire that allows individuals to give their doctor a good description of the quality and intensity of pain that they are experiencing.
A patient's self-reported pain is so critical in the pain assessment method that it has been described as the "most valid measure" of pain. [ 2 ] [ 3 ] The focus on patient report of pain is an essential aspect of any pain scale, but there are additional features that should be included in a pain scale.
Histopathological image of dyshidrotic dermatitis, showing focal spongiotic change in the epidermis. Spongiosis is mainly intercellular [1] edema (abnormal accumulation of fluid) in the epidermis, [2] and is characteristic of eczematous dermatitis, manifested clinically by intraepidermal vesicles (fluid-containing spaces), "juicy" papules, and/or lichenification. [3]
Variable degree of epidermal spongiosis and vesicle formation, filled with proteinaceous fluid containing lymphocytes and histiocytes. Usually superficial dermal edema with perivascular lymphocytic infiltrate, with exocytosis. No acanthosis or parakeratosis. Typical findings: [2] Mild to moderate spongiosis and exocytosis of inflammatory cells
The Joint Commission began setting standards for pain assessment in 2001 stating that the route of analgesic administration dictates the times for pain reassessment, as different routes require different amounts of time for the medication to have a therapeutic effect. Oral: 45–69 minutes. Intramuscular: 30 minutes.
In dermatopathology, the Tzanck test, also Tzanck smear, is scraping of an ulcer base to look for Tzanck cells.It is sometimes also called the chickenpox skin test and the herpes skin test.
The Brief Pain Inventory is a medical questionnaire used to measure pain, developed by the Pain Research Group of the WHO Collaborating Centre for Symptom Evaluation in Cancer Care. The Brief Pain Inventory (BPI) is widely used around the world today to help with measuring a patients' pain intensity and the amount of interference the pain has ...