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Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, [1] seen in diseases such as pemphigus vulgaris. [2] It is absent in bullous pemphigoid , making it useful for differential diagnosis .
Variable degree of epidermal spongiosis and vesicle formation, filled with proteinaceous fluid containing lymphocytes and histiocytes. Usually superficial dermal edema with perivascular lymphocytic infiltrate, with exocytosis. No acanthosis or parakeratosis. Typical findings: [2] Mild to moderate spongiosis and exocytosis of inflammatory cells
Histopathological image of dyshidrotic dermatitis, showing focal spongiotic change in the epidermis. Spongiosis is mainly intercellular [1] edema (abnormal accumulation of fluid) in the epidermis, [2] and is characteristic of eczematous dermatitis, manifested clinically by intraepidermal vesicles (fluid-containing spaces), "juicy" papules, and/or lichenification. [3]
In dermatopathology, the Tzanck test, also Tzanck smear, is scraping of an ulcer base to look for Tzanck cells.It is sometimes also called the chickenpox skin test and the herpes skin test.
Grover's disease (GD) is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis [2]: 529 with or without dyskeratosis. [3] Once confirmed, most cases of Grover's disease last six to twelve months, which is why it was originally called "transient". However it may last much longer.
The Joint Commission began setting standards for pain assessment in 2001 stating that the route of analgesic administration dictates the times for pain reassessment, as different routes require different amounts of time for the medication to have a therapeutic effect. Oral: 45–69 minutes. Intramuscular: 30 minutes.
A patient's self-reported pain is so critical in the pain assessment method that it has been described as the "most valid measure" of pain. [ 2 ] [ 3 ] The focus on patient report of pain is an essential aspect of any pain scale, but there are additional features that should be included in a pain scale.
Pathology image of lymphocytic esophagitis (H&E stain). The image demonstrates common findings in the condition: dense peripapillary lymphocytic infiltrate with spongiosis (arrow), and absence of neutrophils and eosinophils. Specialty: Gastroenterology: Symptoms: difficulty swallowing, heartburn, abdominal pain, food bolus obstruction ...