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Bead probe technology is a probing method used to connect electronic test equipment to the device under test (DUT) within a bed of nails fixture. The technique was first used in the 1990s [ 3 ] and originally given the name “Waygood Bump” after one of the main proponents, Rex Waygood.
A common form of in-circuit testing uses a bed-of-nails tester.This is a fixture that uses an array of spring-loaded pins known as "pogo pins". When a printed circuit board is aligned with and pressed down onto the bed-of-nails tester, the pins make electrical contact with locations on the circuit board, allowing them to be used as test points for in-circuit testing.
Suspension array technology (or SAT) is a high throughput, large-scale, and multiplexed screening platform used in molecular biology.SAT has been widely applied to genomic and proteomic research, such as single nucleotide polymorphism (SNP) genotyping, genetic disease screening, gene expression profiling, screening drug discovery and clinical diagnosis.
On the chip, there are two bead types for each CpG (or "CG", as per Figure 1) site per locus. Each locus tested is differentiated by different bead types. [1] Both bead types are attached to single-stranded 50-mer DNA oligonucleotides that differ in sequence only at the free end; this type of probe is known as an allele-specific oligonucleotide ...
The beads with the resulting PCR products are deposited to a glass slide. Primers hybridize to the P1 adapter sequence within the library template. A set of four fluorescently labelled di-base probes compete for ligation to the sequencing primer.
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Digital bioassay is an example of using protein microarray for diagnostic purposes. In this technology, an array of microwells on a glass/polymer chip are seeded with magnetic beads (coated with fluorescent tagged antibodies), subjected to targeted antigens and then characterised by a microscope through counting fluorescing wells.
[11] [12] Optical tweezers have also been used to probe the cytoskeleton, measure the visco-elastic properties of biopolymers, [13] and study cell motility. A bio-molecular assay in which clusters of ligand coated nano-particles are both optically trapped and optically detected after target molecule induced clustering was proposed in 2011 [ 14 ...