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Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin ...
Cryo-EM structure of the DNA-bound PolD–PCNA processive complex Structural basis for DNA binding by the PolD–PCNA complex. A DNA clamp, also known as a sliding clamp, is a protein complex that serves as a processivity-promoting factor in DNA replication.
AOH1996 was created to target a post-translationally modified isoform of PCNA, termed caPCNA, which is preferentially found in cancer cells. PCNA is crucial in the body for DNA repair, but targeting it is difficult because of its role in healthy cells.
The interactions between the polymerase and the clamp are more persistent than those between the polymerase and the DNA. Thus, when the polymerase dissociates from the DNA, it is still bound to the clamp and can rapidly reassociate with the DNA. An example of such a DNA clamp is PCNA (proliferating cell nuclear antigen) found in S. cervesiae.
A rendering of a fully assembled, trimeric PCNA clamp. Sliding clamp is a generic term that refers to ring-shaped replication factors called beta (bacteria) or PCNA (eukaryotes and archaea). Clamp proteins attract and tether replicative polymerases, such as DNA polymerase III, in order to extend the amount of time that a replicative polymerase ...
CAF-1 contains a PCNA-binding motif, called a PIP-box, that allows CAF-1 to associate with the replisome through PCNA and is able to deposit histone H3-H4 dimers onto newly synthesized DNA. [ 146 ] [ 147 ] The Rtt106 chaperone is also involved in this process, and associated with CAF-1 and H3-H4 dimers during chromatin formation. [ 148 ]
68026 Ensembl ENSG00000166803 ENSMUSG00000040204 UniProt Q15004 Q9CQX4 RefSeq (mRNA) NM_001029989 NM_014736 NM_026515 RefSeq (protein) NP_001025160 NP_055551 NP_080791 Location (UCSC) Chr 15: 64.36 – 64.39 Mb Chr 9: 65.8 – 65.81 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse PCNA-associated factor is a protein that in humans is encoded by the KIAA0101 gene. Interactions KIAA0101 ...
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