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Pregabalin is available as a generic medication in a number of countries, including the United States as of July 2019. [23] [33] [138] In the United States as of July 2019 the wholesale/pharmacy cost for generic pregabalin is US$0.17–0.22 per 150 mg capsule. [140]
[24] [25] Conversely, the oral bioavailability of pregabalin is greater than or equal to 90% across and beyond its entire clinical dose range (75 to 900 mg/day). [24] Food does not significantly influence the oral bioavailability of pregabalin. [24] Conversely, food increases the area-under-curve levels of gabapentin by about 10%. [24]
Gabapentin at a low dose of 100 mg has a T max (time to peak levels) of approximately 1.7 hours, while the T max increases to 3 to 4 hours at higher doses. [85] Food does not significantly affect the T max of gabapentin and increases the C max and area-under-curve levels of gabapentin by approximately 10%.
ACSCN Drug N/A Not more than 200 milligrams of codeine per 100 milliliters or per 100 grams [3] [note 1]: N/A Not more than 100 milligrams of dihydrocodeine per 100 milliliters or per 100 grams [3] [note 1]
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
Pregabalin may help reduce the severity of benzodiazepine withdrawal symptoms, [108] and reduce the risk of relapse. [109] Propranolol was not found to increase the discontinuation success rate. [86] SSRI antidepressants have been found to have little value in the treatment of benzodiazepine withdrawal. [110]
Codeine/paracetamol, also called codeine/acetaminophen and co-codamol, is a compound analgesic, comprising codeine phosphate and paracetamol (acetaminophen). Codeine/paracetamol is used for the relief of mild to moderate pain when paracetamol or non-steroidal anti-inflammatory drugs (NSAIDs; such as ibuprofen, aspirin, and naproxen) alone do not sufficiently relieve symptoms.
Tapentadol, sold under the brand names Nucynta and Palexia among others, is a synthetic opioid analgesic of the benzenoid class with a dual mode of action as a highly selective full agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor (NRI). [7]
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