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Terbutaline, sold under the brand names Bricanyl and Marex among others, is a β 2 adrenergic receptor agonist, used as a "reliever" inhaler in the management of asthma symptoms and as a tocolytic (anti-contraction medication) to delay preterm labor for up to 48 hours.
Terbutaline (Brethine) β 2 agonist: Off-label use, FDA has advised that injectable terbutaline should only be used in urgent situations, and that the oral form of the drug should never be used [9] Cardiac tachyarrhythmias, poorly controlled diabetes mellitus, hyperthyroidism, prolonged tocolysis(>48 to 72 hours) [1]
Salbutamol and terbutaline are also both available in oral forms. [11] In addition, several of these medications are available in intravenous forms, including both salbutamol and terbutaline . It can be used in this form in severe cases of asthma , but it is more commonly used to suppress premature labor because it also relaxes uterine muscle ...
Beta adrenergic agonists or beta agonists are medications that relax muscles of the airways, causing widening of the airways and resulting in easier breathing. [1] They are a class of sympathomimetic agents, each acting upon the beta adrenoceptors. [2]
In the mid-1960s, albuterol or salbutamol was discovered, followed by tributalin and fenoterol a few years later. Albuterol and terbutaline gave fewer side effects, such as increased heart rate, than isoproterenol. The pharmaceutical company Glaxo discovered salmeterol, a long-acting β 2-agonist that had bronchodilation activity for up to 12 ...
Effect only last for 4 – 6 hours for SABAs and 6–9 hours for SAMAs [28] Provided in inhalers → techniques for usage is important for management of COPD [31] Muscarinic antagonist can be considered as more effective than beta2 agonist → reduce the high vagal tone in patients [29] An image of salbutamol inhaler. Caution [32]
Bambuterol is a long-acting β adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a prodrug of terbutaline. Commercially, the AstraZeneca pharmaceutical company produces and markets bambuterol as Bambec and Oxeol .
Uterine hyperstimulation or hypertonic uterine dysfunction is a potential complication of labor induction.This is displayed as Uterine tachysystole- the contraction frequency numbering more than five in a 10-minute time frame or as contractions exceeding more than two minutes in duration. [1]