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General paresis, also known as general paralysis of the insane (GPI), paralytic dementia, or syphilitic paresis is a severe neuropsychiatric disorder, classified as an organic mental disorder, and is caused by late-stage syphilis and the chronic meningoencephalitis and cerebral atrophy that are associated with this late stage of the disease when left untreated.
The signs and symptoms of neurosyphilis vary with the disease stage of syphilis. The stages of syphilis are categorized as primary, secondary, latent, and tertiary. It is important to note that neurosyphilis may occur at any stage of infection. [citation needed] Meningitis is the most-common neurological presentation in early syphilis. It ...
Syphilis (/ ˈ s ɪ f ə l ɪ s /) is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. [1] The signs and symptoms depend on the stage it presents: primary, secondary, latent or tertiary.
Tabes dorsalis is caused by demyelination by advanced syphilis infection (tertiary syphilis) when the primary infection by the causative spirochete bacterium, Treponema pallidum, is left untreated for an extended period of time (past the point of blood infection by the organism). [3]
Meningeal syphilis (as known as syphilitic aseptic meningitis or meningeal neurosyphilis) is a chronic form of syphilis infection that affects the central nervous system. Treponema pallidum , a spirochate bacterium, is the main cause of syphilis, which spreads drastically throughout the body and can infect all its systems if not treated ...
Ernst von Feuchtersleben is also widely credited as introducing the term in 1845, [152] as an alternative to insanity and mania. The term stems from Modern Latin psychosis , "a giving soul or life to, animating, quickening" and that from Ancient Greek ψυχή ( psyche ), "soul" and the suffix -ωσις (- osis ), in this case "abnormal condition".
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Nietzsche's insanity was originally diagnosed as tertiary syphilis, in accordance with a prevailing medical paradigm of the time. Although most commentators [ who? ] regard his breakdown as unrelated to his philosophy, Georges Bataille wrote poetically of his condition ("'Man incarnate' must also go mad") [ 83 ] and René Girard 's postmortem ...