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Overall, these findings validate inhibition of RUNX1- CBFβ-SMMHC protein-protein interaction as a novel therapeutic avenue for leukemia with inv(16) and AI-10-49 as a specific inhibitor of CBFβ-SMHHC oncoprotein. The discovery of AI-10-49 provides additional evidence that transcription factor drivers of cancer can be directly targeted.
In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype.
An inversion is a chromosome rearrangement in which a segment of a chromosome becomes inverted within its original position. An inversion occurs when a chromosome undergoes a two breaks within the chromosomal arm, and the segment between the two breaks inserts itself in the opposite direction in the same chromosome arm.
The pericentric inversion of the Y-chromosome (inv(Y)) is a rare chromosomal heteromorphism which is hereditary. It has no clinical significance or reproductive disadvantage. [22] It is studied in Gujarati Muslims of South Africa, 8 inv(Y) men opposed to 9 normal men.
Sylvein William Maximilian D’Habsburg XVII, 48, has been accused of taking more than $5.9 million from victims over the course of several years. It was all under the guise of investing in his ...
A breakage and reunion in the pericentric region of the p arm results in a dicentric isochromosome. [4] Some of the p arm can be found in this formation of i(Xq), but a majority of the genetic material on the p arm is lost so it is considered absent.
Luigi Mangione, the man accused of gunning down UnitedHealthcare CEO Brian Thompson, will waive extradition to New York when he appears in court in Pennsylvania on Thursday, his attorney said ...
$5.50 off each 24-pack of 16.9-ounce bottles. If you're tackling Dry January, San Pellegrino sparkling mineral water is a great way to mix things up.The 24-pack of 16.9-ounce bottles is $5.50 off ...