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The Meyer-Overton correlation for anaesthetics. A nonspecific mechanism of general anaesthetic action was first proposed by Emil Harless and Ernst von Bibra in 1847. [9] They suggested that general anaesthetics may act by dissolving in the fatty fraction of brain cells and removing fatty constituents from them, thus changing activity of brain cells and inducing anaesthesia.
Procaine is a local anesthetic drug of the amino ester group. It is most commonly used in dental procedures to numb the area around a tooth [1] and is also used to reduce the pain of intramuscular injection of penicillin. Owing to the ubiquity of the trade name Novocain or Novocaine, in some regions, procaine is referred to generically as ...
The Lateral Pressure Profile theory suggests that anesthetic agents partition into the lipid bilayer, increasing the horizontal pressure on proteins imbedded in the membrane. The added pressure causes a conformational change in protein structure , forcing the neuronal channel into an open or closed state (e.g., hyperpolarization ) that ...
Procaine's ability to retard certain wound healing processes has been well researched. [13] He hypothesized that these processes were DNA controlled with procaine interaction. DeMarco believed his chemically induced partial limb regeneration, scar tissue repression and coordinated tissue repair was a significant step forward in human ...
This is a list of local anesthetic agents. Not all of these drugs are still used in clinical practice and in research. ... Novocain, borocaine (procaine borate ...
Many local anesthetics fall into two general chemical classes, amino esters (top) and amino amides (bottom). A local anesthetic (LA) is a medication that causes absence of all sensation (including pain) in a specific body part without loss of consciousness, [1] providing local anesthesia, as opposed to a general anesthetic, which eliminates all sensation in the entire body and causes ...
Alfred Einhorn (27 February 1856 – 21 March 1917) was a German chemist most notable for first synthesizing procaine in 1905 which he patented under the name Novocain. [2] Until that time the primary anesthetic in use was cocaine , however its undesirable side effects (including toxicity and addiction ) led scientists to seek out newer ...
From these conclusions about plants and animals, two of the three tenets of cell theory were postulated. 1. All living organisms are composed of one or more cells 2. The cell is the most basic unit of life. Schleiden's theory of free cell formation through crystallization was refuted in the 1850s by Robert Remak, Rudolf Virchow, and Albert ...