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Hypothermia is defined as a body core temperature below 35.0 °C (95.0 °F) in humans. [2] Symptoms depend on the temperature. In mild hypothermia, there is shivering and mental confusion. In moderate hypothermia, shivering stops and confusion increases. [3]
Melioidosis is an infectious disease caused by a gram-negative bacterium called Burkholderia pseudomallei. [1] Most people exposed to B. pseudomallei experience no symptoms; however, those who do experience symptoms have signs and symptoms that range from mild, such as fever and skin changes, to severe with pneumonia, abscesses, and septic shock that could cause death. [1]
Mucolipidosis II (I-cell disease) Fucosidosis; Aspartylglucosaminuria; Alpha-mannosidosis; Other Wolman disease (acid lipase deficiency) Immunodeficiencies. T-cell deficiencies Ataxia-telangiectasia; DiGeorge syndrome; Combined T- and B-cell deficiencies Severe combined immunodeficiency (SCID), all types; Well-defined syndromes Wiskott ...
Cold agglutinin disease (CAD) is a rare autoimmune disease characterized by the presence of high concentrations of circulating cold sensitive antibodies, usually IgM and autoantibodies that are also active at temperatures below 30 °C (86 °F), [1] directed against red blood cells, causing them to agglutinate and undergo lysis. [2]
Stem-cell therapy uses stem cells to treat or prevent a disease or condition. [1] As of 2024, the only FDA-approved therapy using stem cells is hematopoietic stem cell transplantation. [2] [3] This usually takes the form of a bone marrow or peripheral blood stem cell transplantation, but the cells can also be derived from umbilical cord blood.
In humans, the average internal temperature is widely accepted to be 37 °C (98.6 °F), a "normal" temperature established in the 1800s. But newer studies show that average internal temperature for men and women is 36.4 °C (97.5 °F). [10] No person always has exactly the same temperature at every moment of the day.
Cold agglutinins are antibodies, typically immunoglobulin M (), that are acquainted with and then binding the antigens on red blood cells, typically antigens "I" or "i" on the RBC surface, [1] in the environment in which the temperatures are lower than normal core body temperature and, thus, ends up leading to agglutinations of the red blood cells and hemolysis reaction occurring outside the ...
The bacteria uses the cytoplasmic membrane, RNA/DNA, and ribosomes as cold sensors in the cell, placing them in charge of monitoring the cell's temperature. [6] Once these sensors send the signal that a cold shock is occurring, the bacteria will pause the majority of protein synthesis in order to redirect its focus to producing what are called ...