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Serum sickness in humans is a reaction to proteins in antiserum derived from a non-human animal source, occurring 5–10 days after exposure. Symptoms often include a rash , joint pain , fever , and lymphadenopathy .
Antivenoms are purified from animal serum by several processes and may contain other serum proteins that can act as immunogens.Some individuals may react to the antivenom with an immediate hypersensitivity reaction (anaphylaxis) or a delayed hypersensitivity (serum sickness) reaction, and antivenom should, therefore, be used with caution.
The most common diseases involving a type III hypersensitivity reaction are serum sickness, post-streptococcal glomerulonephritis, systemic lupus erythematosus, farmers' lung (hypersensitivity pneumonitis), and rheumatoid arthritis.
a group of blood tests, commonly called a basic metabolic panel (blood urea nitrogen, carbon dioxide, creatinine, glucose, serum chloride, serum potassium, serum sodium) CHEM-20
Laboratory abnormalities include normal or mild decreases in serum C3, C4, and CH50 levels, and mild proteinuria. In contrast to true serum sickness, renal and hepatic involvement is rare. Significant decreases in serum C3, C4, and CH50, reported in the literature for true serum sickness, are rarely described in serum sickness–like reaction.
[25] [26] The serum-sickness–like syndrome occurs in the setting of acute hepatitis B, often preceding the onset of jaundice. [27] The clinical features are fever, skin rash, and polyarteritis. The symptoms often subside shortly after the onset of jaundice but can persist throughout the duration of acute hepatitis B. [28]
Taking precautions to protect yourself from a quartet of infectious diseases can lessen your odds of starting off 2025 sick.
Concentration and sterility of the serum were checked carefully, and the serum was filtered many times. Protein content was decreased in order to use the serum for humans. After the blood sampling, the horses could rest for three to four weeks and received extra food to recover the blood loss.