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This is a list of musical compositions or pieces of music that have unusual time signatures. "Unusual" is here defined to be any time signature other than simple time signatures with top numerals of 2, 3, or 4 and bottom numerals of 2, 4, or 8, and compound time signatures with top numerals of 6, 9, or 12 and bottom numerals 4, 8, or 16.
Most time signatures consist of two numerals, one stacked above the other: The lower numeral indicates the note value that the signature is counting. This number is always a power of 2 (unless the time signature is irrational), usually 2, 4 or 8, but less often 16 is also used, usually in Baroque music. 2 corresponds to the half note (minim), 4 to the quarter note (crotchet), 8 to the eighth ...
Exon shuffling is a molecular mechanism for the formation of new genes. It is a process through which two or more exons from different genes can be brought together ectopically, or the same exon can be duplicated, to create a new exon-intron structure. [1]
Across all eukaryotic genes in GenBank, there were (in 2002), on average, 5.48 exons per protein coding gene. The average exon encoded 30-36 amino acids. [7] While the longest exon in the human genome is 11555 bp long, several exons have been found to be only 2 bp long. [8] A single-nucleotide exon has been reported from the Arabidopsis genome. [9]
This mechanism is an example of exon definition in splicing. A spliceosome assembles on an intron, and the snRNP subunits fold the RNA so that the 5' and 3' ends of the intron are joined. However, recently studied examples such as this one show that there are also interactions between the ends of the exon.
RNA-Seq can also be used to determine exon/intron boundaries and verify or amend previously annotated 5' and 3' gene boundaries. Recent advances in RNA-Seq include single cell sequencing , bulk RNA sequencing , [ 6 ] 3' mRNA-sequencing , in situ sequencing of fixed tissue, and native RNA molecule sequencing with single-molecule real-time ...
The genomic fragment is inserted into the intron of a 'splicing vector' consisting of a known exon - intron - exon sequence of DNA, and the vector is then inserted into an eukaryotic cell. If the fragment does not contain exons (i.e., consists solely of intron DNA), it will be spliced out together with the vector's original intron.
The word intron is derived from the term intragenic region, i.e., a region inside a gene. [1] The term intron refers to both the DNA sequence within a gene and the corresponding RNA sequence in RNA transcripts. [2] The non-intron sequences that become joined by this RNA processing to form the mature RNA are called exons. [3]