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It is associated with the binding and unbinding reaction of receptor (R) and ligand (L) molecules, which is formalized as: R + L ⇌ RL. The reaction is characterized by the on-rate constant k on and the off-rate constant k off, which have units of M −1 s −1 and s −1, respectively. In equilibrium, the forward binding transition R + L → ...
The dissociation rate constant is defined using K off. [2] The Michaelis-Menten constant is denoted by K m and is represented by the equation K m = (K off + K cat)/ K on [definition needed]. The rates that the enzyme binds and dissociates from the substrate are represented by K on and K off respectively.
When each receptor has a single ligand binding site, the system is described by [] + [] [] with an on-rate (k on) and off-rate (k off) related to the dissociation constant through K d =k off /k on. When the system equilibrates,
In coordination chemistry, a stability constant (also called formation constant or binding constant) is an equilibrium constant for the formation of a complex in solution. It is a measure of the strength of the interaction between the reagents that come together to form the complex. There are two main kinds of complex: compounds formed by the ...
Receptor–ligand binding kinetics also involves the on- and off-rates of binding. A main goal of receptor–ligand kinetics is to determine the concentrations of the various kinetic species (i.e., the states of the receptor and ligand) at all times, from a given set of initial concentrations and a given set of rate constants.
The symbol K a, used for the acid dissociation constant, can lead to confusion with the association constant, and it may be necessary to see the reaction or the equilibrium expression to know which is meant. Acid dissociation constants are sometimes expressed by pK a, which is defined by
A mathematical constant is a key number whose value is fixed by an unambiguous definition, often referred to by a symbol (e.g., an alphabet letter), or by mathematicians' names to facilitate using it across multiple mathematical problems. [1]
Molecular binding is an attractive interaction between two molecules that results in a stable association in which the molecules are in close proximity to each other. It is formed when atoms or molecules bind together by sharing of electrons. It often, but not always, involves some chemical bonding.