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This is an example of a linear free energy relationship as log(K a) is proportional to the standard free energy change. Hammett originally [51] formulated the relationship with data from benzoic acid with different substituents in the ortho-and para-positions: some numerical values are in Hammett equation.
In computational biology, protein pK a calculations are used to estimate the pK a values of amino acids as they exist within proteins.These calculations complement the pK a values reported for amino acids in their free state, and are used frequently within the fields of molecular modeling, structural bioinformatics, and computational biology.
Its conjugate base is the acetate ion with K b = 10 −14 /K a = 5.7 x 10 −10 (from the relationship K a × K b = 10 −14), which certainly does not correspond to a strong base. The conjugate of a weak acid is often a weak base and vice versa .
In chemistry and biochemistry, the Henderson–Hasselbalch equation = + ([] []) relates the pH of a chemical solution of a weak acid to the numerical value of the acid dissociation constant, K a, of acid and the ratio of the concentrations, [] [] of the acid and its conjugate base in an equilibrium.
In chemistry, biochemistry, and pharmacology, a dissociation constant (K D) is a specific type of equilibrium constant that measures the propensity of a larger object to separate (dissociate) reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into its component ions.
A plot of log(k) against log(K A) showed a linear relationship. Such linear relationships correspond to linear free energy relationships, which strongly imply that the effect of the substituents are exerted through changes of potential energy and that the steric and entropy terms remain almost constant through the series.
In cell biology, protein kinase A (PKA) is a family of serine-threonine kinase [1] whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase (EC 2.7.11.11). PKA has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.
The data should have a linear relationship, the equation for which can be found by fitting the data using the linear form of the Van 't Hoff equation ln K e q = − Δ r H ⊖ R T + Δ r S ⊖ R . {\displaystyle \ln K_{\mathrm {eq} }=-{\frac {\Delta _{r}H^{\ominus }}{RT}}+{\frac {\Delta _{r}S^{\ominus }}{R}}.}