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Nikolsky's sign is a clinical dermatological sign, named after Pyotr Nikolsky (1858–1940), a Russian physician who trained and worked in the Russian Empire. The sign is present when slight rubbing of the skin results in exfoliation of the outermost layer.
The Asboe-Hansen sign (also known as "indirect Nikolsky sign'" [1] or "Nikolsky II sign" [1]) refers to the extension of a large blister to adjacent unblistered skin when pressure is put on the top of it.
Pyotr Vasilyevich Nikolsky (Russian: Пётр Васи́льевич Нико́льский; September 13 [O.S. September 1] 1858 – March 13, 1940) was an Imperial Russian and later Soviet dermatologist.
SSSS is a clinical diagnosis. This is sometimes confirmed by isolation of S. aureus from blood, mucous membranes, or skin biopsy; however, these are often negative. Skin biopsy may show separation of the superficial layer of the epidermis (intraepidermal separation), differentiating SSSS from TEN, wherein the separation occurs at the dermo-epidermal junction (subepidermal separation).
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Nikolsky's sign (gentle lateral pressure) on unaffected mucosa or skin raises a bulla. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion. If no lesions are present on examination it may be useful way of demonstrating reduced epithelial adhesion.
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Leser–Trélat sign; N. Nikolsky's sign; Nodule (medicine) R. Renbök phenomenon; Rumpel–Leede sign; W. Wickham striae; Wolf's isotopic response