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In 2006, the United States Food and Drug Administration revoked its previous approval of hydroquinone and proposed a ban on all over-the-counter preparations. [25] The FDA officially banned hydroquinone in 2020 as part of a larger reform of the over-the-counter drug review process. [26]
Another quinone-containing drug is Mecarbinate (dimecarbine), made by the reaction of ethyl N-methyl-β-aminocrotonate with para-benzoquinone. Others include Amendol, Oxyphemedol, Phemedol all in FR5142 (M) ― 1967-06-05. [clarification needed] Note: These are all indoles made via the Nenitzescu indole synthesis.
Hydroquinone is a commonly used agent in skin whiteners. The European Union banned it from cosmetics in 2000. [9] It works by decreasing melanin production. [9] Tretinoin, also known as all-trans retinoic acid, may be used to whiten specific areas. [6] It may be used in combination with steroids and hydroquinone. [6]
Monobenzone, also called 4-(Benzyloxy)phenol and monobenzyl ether of hydroquinone (MBEH) is an organic chemical in the phenol family with chemical formula C 6 H 5 CH 2 OC 6 H 4 OH. [1] [2] It is used as a topical drug for medical depigmentation. [3] It is a colourless solid that is classified as the monobenzyl ether of hydroquinone.
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Fluocinolone acetonide (0.01%)/Hydroquinone (4%)/ Tretinoin (0.05%) Cream is indicated for the short-term (up to 8 weeks) treatment of moderate to severe melasma of the face in the presence of measures for sun avoidance, including the use of sunscreens.
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The European Food Safety Authority (EFSA) and the United States Food and Drug Administration (FDA) [3] have evaluated TBHQ and determined that it is safe to consume at the concentration allowed in foods. [4] The FDA [5] and European Union [4] both set an upper limit of 0.02% (200mg/kg) of the oil or fat content in foods. At very high doses, it ...