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Vitamin C megadosage is a term describing the consumption or injection of vitamin C (ascorbic acid) in doses well beyond the current United States Recommended Dietary Allowance of 90 milligrams per day, and often well beyond the tolerable upper intake level of 2,000 milligrams per day. [1]
Vitamin C supplements among other dietary supplements at a US drug store. Vitamin C has a definitive role in treating scurvy, which is a disease caused by vitamin C deficiency. Beyond that, a role for vitamin C as prevention or treatment for various diseases is disputed, with reviews often reporting conflicting results.
[10] [11] A systematic review of trials in 2021 found that the claimed benefits of the protocol could not be confirmed. [12] People in sepsis may have micronutrient deficiencies, including low levels of vitamin C. [13] Reviews mention that an intake of 3.0 g/day via intravenous administration may needed to maintain normal plasma concentrations.
[106] [107] A study using 250 mg and 1000 mg doses of vitamin C along with other antioxidants to treat people with AIDS did not find any benefit. [ 108 ] A meta analysis in 2010 (updated in 2017 with different results) found that micronutrient supplementation decreased the risk of death and improved outcomes in pregnant women with HIV in Africa.
Vitamin C and the Common Cold is a popular book by Linus Pauling, first published in 1970, on vitamin C, its interactions with common cold and the role of vitamin C megadosage in human health. [1] The book promoted the idea that taking large amounts of vitamin C could reduce the duration and severity of the common cold. A Nobel Prize-winning ...
C 6 H 6 O 6 • − + L• + H 2 O + H + → C 6 H 8 O 7 + LH 2 C 6 H 6 O 6 • − + H 2 O + H + → C 6 H 8 O 7 + C 6 H 7 O − 6. Aqueous solutions of dehydroascorbate are unstable, undergoing hydrolysis with a half-life of 5–15 minutes at 37 °C (99 °F). Decomposition products include diketogulonic acid, xylonic acid, threonic acid and ...
I've listed this article for peer review because as a person with a degree in nutritional biochemistry, I want to know if the content is understandable to people without an advanced science /medical/health background. FYI - I raised this article to GA back in 2017 and have been working on it starting in December 2023 with intent to nominate to FA.
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