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Methotrexate was originally developed and continues to be used for chemotherapy, either alone or in combination with other agents.It is effective for the treatment of several cancers, including solid tumours of breast, head and neck, lung, bladder, as well as acute lymphocytic leukemias, non-Hodgkin's lymphoma, osteosarcoma, and choriocarcinoma and other trophoblastic neoplasms.
Folic acid may be given weekly to help diminish the frequency of side-effects. [12] Methotrexate is also associated with acute and chronic liver damage. Other adverse effects include: [12] Life-threatening Interstitial lung disease; Tubular necrosis; Renal failure; Skin reactions; Alopecia; Ocular irritation.
Low doses of methotrexate can deplete folate stores and cause side-effects that are similar to folate deficiency. Both high-folate diets and supplemental folic acid may help reduce the toxic side-effects of low-dose methotrexate without decreasing its effectiveness.
For example, rheumatoid arthritis is often treated with methotrexate and leflunomide, both of which suppresses chronic inflammation. ... Sometimes, hair loss is a side effect of your medication.
The side effects of the administration of the chemotherapeutic agents used in hyper-CVAD are complex, and are often dependent on the overall health of the patient. Hematologic and immune system The majority of patients will experience a degree of pancytopenia , including anaemia , thrombocytopenia , and leukopenia , due to the myelosuppressive ...
Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine. [2] [3] It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, may be used to treat folate deficiency that results in anemia, and methanol poisoning.