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The most common adverse effects for losartan in adults are upper respiratory infections, dizziness, and back pain. [3] People with type 2 diabetes and kidney disease may experience diarrhea , fatigue, low blood pressure, low blood glucose, elevated potassium, chest pain, or allergic reaction . [ 3 ]
Amlodipine, sold under the brand name Norvasc among others, is a calcium channel blocker medication used to treat high blood pressure, coronary artery disease (CAD) [10] and variant angina (also called Prinzmetal angina or coronary artery vasospasm, among other names). [11]
Losartan, the first ARB. Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT 1) antagonists, [1] also known as angiotensin receptor blockers, [2] [3] angiotensin II receptor antagonists, or AT 1 receptor antagonists, are a group of pharmaceuticals that bind to and inhibit the angiotensin II receptor type 1 (AT 1) and thereby block the arteriolar contraction and ...
Losartan, valsartan, candesartan, irbesartan, telmisartan and olmesartan all contain a biphenyl-methyl group. Losartan is partly metabolized to its 5- carboxylic acid metabolite EXP 3174, which is a more potent AT 1 receptor antagonist than its parent compound [ 17 ] and has been a model for the continuing development of several other ARBs.
The scarring of the small blood vessels, called capillary sclerosis, is the initial lesion of analgesic nephropathy. [7] Found in the renal pelvis, ureter, and capillaries supplying the nephrons, capillary sclerosis is thought to lead to renal papillary necrosis and, in turn, chronic interstitial nephritis.
Versions are available as the combination olmesartan/hydrochlorothiazide and olmesartan/amlodipine. [2] It is available as a prodrug, olmesartan medoxomil. Common side effects include dizziness, headaches, diarrhea, and back pain. [2] Serious side effects may include kidney problems, low blood pressure, and angioedema. [2]
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URAT1 is the central mediator in the transport of uric acid from the kidney into the blood. In some persons with loss-of-function mutations of URAT1, the uricosurics benzbromarone and losartan had no effect, suggesting these drugs act on URAT1 in vivo. [1] Thus, uricosuric drugs may be candidates for management in a personalized medicine model.
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